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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
US Army
Covington
Farmers Insurance
McKesson
Cipla
Federal Trade Commission
Moodys
Accenture

Generated: June 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,888,027

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Which drugs does patent 6,888,027 protect, and when does it expire?

Patent 6,888,027 protects BELEODAQ and is included in one NDA.

This patent has sixteen patent family members in eleven countries.
Summary for Patent: 6,888,027
Title: Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
Abstract:This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q.sup.1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: --S(.dbd.O).sub.2 NR.sup.1 -- and --NR.sup.1 S(.dbd.O).sub.2 --; R1 is a sulfonamido substituent; and, Q.sup.2 is an acid leader group; with the proviso that if J is --S(.dbd.O).sub.2 NR.sup.1 --, then Q.sup.1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis. ##STR1##
Inventor(s): Watkins; Clare J (Abingdon, GB), Romero-Martin; Maria Rosario (Didcot, GB), Moore; Kathryn G (Abingdon, GB), Ritchie; James (Abingdon, GB), Finn; Paul W (Abingdon, GB), Kalvinsh; Ivars (Riga, LV), Loza; Einars (Riga, LV), Dikovska; Klara (Riga, LV), Gailite; Vija (Riga, LV), Vorona; Maxim (Riga, LV), Piskunova; Irina (Riga, LV), Starchenkov; Igor (Riga, LV), Andrianov; Victor (Riga, LV), Harris; C. John (Sittingbourne, GB), Duffy; James E. S. (Sittingbourne, GB)
Assignee: Topotarget UK Limited (Abingdon, GB)
Application Number:10/381,790
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 6,888,027

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Spectrum Pharms BELEODAQ belinostat POWDER;IV (INFUSION) 206256-001 Jul 3, 2014 RX Yes Yes ➤ Sign Up ➤ Sign Up Y Y TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA (PTCL). ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 6,888,027

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom0023986Sep 29, 2000
PCT Information
PCT FiledSeptember 27, 2001PCT Application Number:PCT/GB01/04326
PCT Publication Date:April 18, 2002PCT Publication Number: WO02/30879

Non-Orange Book US Patents Family Members for Patent 6,888,027

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,183,298 Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors ➤ Sign Up
7,557,140 Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors ➤ Sign Up
7,407,988 Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
Mallinckrodt
Julphar
McKesson
Cerilliant
Chinese Patent Office
Argus Health
Harvard Business School
Johnson and Johnson

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