Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof
Abstract:
A transdermal therapeutic system, comprising a backing layer inert to the components of the matrix, a self-adhesive matrix layer containing (-)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol in an effective amount and a protective foil or sheet to be removed prior to use, is characterised by a matrix that is based on a non-aqueous, acrylate-based or silicone-based polymer adhesive system having a solubility of .gtoreq.5% (w/w) for (-)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]-amino]-1-naphthaleno l, and said matrix is substantially free of inorganic silicate particulates.
Inventor(s):
Muller; Walter (Neuwied, DE), Peck; James V. (Richmond, VA)
Assignee:
LTS Lohmann Therapie-Systeme AG (Andernach, DE) Aderis Pharmaceuticals, Inc. (Richmond, VA)
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