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Details for Patent: 6,852,689

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Summary for Patent: 6,852,689

Title: Methods for administration of antibiotics
Abstract:The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that dos not result in muscle toxicity.
Inventor(s): Oleson, Jr.; Frederick B. (Concord, MA), Tally; Francis P. (Lincoln, MA)
Assignee: Cubist Pharmaceuticals, Inc. (Lexington, MA)
Application Number:10/082,544
Patent Claim Types:
see list of patent claims
Patent Metrics:
Source: PatentQuant.com
Field: Not categorized
Back Citations: 11th percentile
Forward Citations: 0th percentile

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International Patent Family for Patent: 6,852,689

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Russian Federation2363489► subscribe
Russian Federation2004106569► subscribe
Russian Federation2232592► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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