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Details for Patent: 6,818,226

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Patent 6,818,226 protects AXIRON and EVAMIST and is included in two NDAs. There has been one Paragraph IV challenge on Axiron. There are two tentative approvals for the compound protected by this patent. Additional details are available via the generic ingredient links below.

This patent has thirty-two patent family members in thirteen countries.

Summary for Patent: 6,818,226

Title: Dermal penetration enhancers and drug delivery systems involving same
Abstract:A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.
Inventor(s): Reed; Barry Leonard (Strathmore, AU), Morgan; Timothy Matthias (Parkville, AU), Finnin; Barrie Charles (Glen Iris, AU)
Assignee: ACRUX DDS Pty. Ltd. (Victoria, AU)
Application Number:09/910,780
Patent Claim Types:
see list of patent claims
Delivery; Compound; Use; Device;
Patent Metrics:
Source: PatentQuant.com
Field: Pharmaceuticals
Back Citations: 30th percentile
Forward Citations: 7th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Eli Lilly And Co
AXIRON
testosterone
SOLUTION, METERED;TRANSDERMAL022504-001Nov 23, 2010RXYes6,818,226► subscribeY TESTOSTERONE REPLACEMENT THERAPY IN MALES FOR CONDITIONS ASSOCIATED WITH A DEFICIENCY OR ABSENCE OF ENDOGENOUS TESTOSTERONE
Elan Pharma Intl Ltd
EVAMIST
estradiol
SPRAY;TRANSDERMAL022014-001Jul 27, 2007RXYes6,818,226► subscribeY MENOPAUSAL AND POSTMENOPAUSAL DISORDERS (INCLUDING VASOMOTOR SYMPTOMS ASSOCCIATED WITH MENOPAUSE)
Elan Pharma Intl Ltd
EVAMIST
estradiol
SPRAY;TRANSDERMAL022014-001Jul 27, 2007RXYes6,818,226► subscribeY FEMALE HORMONE REPLACEMENT THERAPY FOR POSTMENOPAUSAL WOMEN
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Foreign Priority and PCT Information for Patent: 6,818,226

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
AustraliaPN8144/96Feb 19, 1996

Non-Orange Book Patents for Patent: 6,818,226

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,299,900 Dermal penetration enhancers and drug delivery systems involving same► subscribe
8,071,075Dermal penetration enhancers and drug delivery systems involving the same► subscribe
6,998,138Topical delivery of anti-alopecia agents► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 6,818,226

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria324865► subscribe
Austria410136► subscribe
Austria472997► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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