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Details for Patent: 6,762,180

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Patent 6,762,180 protects OFEV and is included in one NDA.

This patent has fifty-three patent family members in forty countries.

Summary for Patent: 6,762,180

Title: Substituted indolines which inhibit receptor tyrosine kinases
Abstract:Indolinones of the formula ##STR1## having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycar bonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoy l-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxyca rbonyl-2-indolinone.
Inventor(s): Roth; Gerald Juergen (Biberach, DE), Heckel; Armin (Biberach, DE), Walter; Rainer (Biberach, DE), Van Meel; Jacobus (Moedling, AT), Redemann; Norbert (Biberach, DE), Tontsch-Grunt; Ulrike (Baden, AT), Spevak; Walter (Oberrohrbach, AT), Hilberg; Frank (Vienna, AT)
Assignee: Boehringer Ingelheim Pharma KG (Ingelheim, DE)
Application Number:09/678,682
Patent Claim Types:
see list of patent claims
Compound; Composition;
Patent Metrics:
Source: PatentQuant.com
Field: Organic fine chemistry
Back Citations: 8th percentile
Forward Citations: 6th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Boehringer Ingelheim
nintedanib esylate
CAPSULE;ORAL205832-001Oct 15, 2014RXNo6,762,180Dec 10, 2020YY
Boehringer Ingelheim
nintedanib esylate
CAPSULE;ORAL205832-002Oct 15, 2014RXYes6,762,180Dec 10, 2020YY
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Foreign Priority and PCT Information for Patent: 6,762,180

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany199 49 208Oct 13, 1999
Germany100 42 696Aug 31, 2000

International Patent Family for Patent: 6,762,180

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hungary0204587<disabled in preview>
Hungary230416<disabled in preview>
CroatiaP20020306<disabled in preview>
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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