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Details for Patent: 6,676,967

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Summary for Patent: 6,676,967

Title: Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
Abstract:Methods for reducing flushing in individuals being treated for hyperlipidemia with nicotinic acid are disclosed. According to the methods of the present invention, flushing can be reduced in individuals under going nicotinic acid therapy without causing drug-induced hepatotoxicity to a level that would require the nicotinic acid therapy to be discontinued by orally administering to the individuals intermediate nicotinic acid formualtions having unique biopharmaceutical characteristics as a single dose once per day. While the methods of the present invention contemplate administering the intermediate release nicotinic acid formulations at any time during a 24 hour period, it is preferable to administer them once-a-day as a single dose during the evening or at night between about 6:00 pm. and 12:00 a.m., preferably between about 8:00 p.m. and 12:00 a.m., and most preferably between about 8:00 p.m. and 10:00 p.m.
Inventor(s): Cefali; Eugenio A. (Fort Lauderdale, FL), Bova; David J. (Boca Raton, FL)
Assignee: KOS Pharmaceuticals, Inc. (Miami, FL)
Application Number:08/962,422
Patent Claim Types:
see list of patent claims
Use; Formulation; Dosage form; Device;
Patent Metrics:
Source: PatentQuant.com
Field: Pharmaceuticals
Back Citations: 285th percentile
Forward Citations: 0th percentile

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International Patent Family for Patent: 6,676,967

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office0966284<disabled in preview>
European Patent Office0969837<disabled in preview>
European Patent Office2319513<disabled in preview>
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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