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|Title:||Pediatric formulation of gatifloxacin|
|Abstract:||There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.|
|Inventor(s):||Raghavan; Krishnaswamy S. (Cranbury, NJ), Ranadive; Sunanda A. (East Brunswick, NJ), Bembenek; Kenneth S. (Dayton, NJ), Benkerrour; Loutfy (Paris, FR), Trognon; Veronique (La Turballe, FR), Corrao; Richard G. (Jackson, NJ), Esposito; Luigi (Howell, NJ)|
|Assignee:||Bristol-Myers Squibb Company (Princeton, NJ)|
Patent Claim Types:|
see list of patent claims
|Compound; Composition; Dosage form; Use; Process;|
Back Citations: 13th percentile
Forward Citations: 0th percentile
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