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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
US Army
Teva
Healthtrust
Cerilliant
UBS
US Department of Justice
Accenture
QuintilesIMS

Generated: June 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,479,500

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Which drugs does patent 6,479,500 protect, and when does it expire?

Patent 6,479,500 protects LONSURF and is included in one NDA.

This patent has twelve patent family members in eleven countries.
Summary for Patent: 6,479,500
Title: Agents for alleviating side effects
Abstract:The present invention provides an agent for alleviating side effects caused by use of an anti-tumor agent, which contains 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidi nedione (1) represented by formula (1): ##STR1## or a pharmaceutically acceptable salt thereof. The 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a pharmaceutically acceptable salt thereof exhibit an inflammatory-suppressing action in the digestive tract and advantageously alleviate diarrhea and loss of body weight concomitant with administration of a chemical for treating cancer without suppressing the anti-tumor effect. Thus, the compounds of the present invention are of great value as agents for alleviating side effects caused by use of an anti-tumor agent, which enable not only the chemotherapy to be continuedly carried out, but also the body exhaustion to be effectively prevented.
Inventor(s): Fukushima; Masakazu (Hannou, JP), Yamamoto; Noriyuki (Sayama, JP), Suzuki; Norihiko (Hidaka, JP)
Assignee: Taiho Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:09/701,041
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 6,479,500

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Taiho Oncology LONSURF tipiracil hydrochloride; trifluridine TABLET;ORAL 207981-001 Sep 22, 2015 RX Yes No ➤ Sign Up ➤ Sign Up TREATMENT OF PATIENTS WITH METASTATIC COLORECTAL CANCER WHO HAVE BEEN PREVIOUSLY TREATED WITH FLUOROPYRIMIDINE-, OXALIPLATIN- AND IRINOTECAN-BASED CHEMOTHERAPY, AN ANTI-VEGF BIOLOGICAL THERAPY, AND IF RAS WILD-TYPE, AN ANTI-EGFR THERAPY ➤ Sign Up
Taiho Oncology LONSURF tipiracil hydrochloride; trifluridine TABLET;ORAL 207981-002 Sep 22, 2015 RX Yes Yes ➤ Sign Up ➤ Sign Up TREATMENT OF PATIENTS WITH METASTATIC COLORECTAL CANCER WHO HAVE BEEN PREVIOUSLY TREATED WITH FLUOROPYRIMIDINE-, OXALIPLATIN- AND IRINOTECAN-BASED CHEMOTHERAPY, AN ANTI-VEGF BIOLOGICAL THERAPY, AND IF RAS WILD-TYPE, AN ANTI-EGFR THERAPY ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 6,479,500

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan11-77579Mar 23, 1999
PCT Information
PCT FiledMarch 16, 2000PCT Application Number:PCT/JP00/01607
PCT Publication Date:September 28, 2000PCT Publication Number: WO00/56337

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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Colorcon
Mallinckrodt
Cipla
Covington
Farmers Insurance
Accenture
Fish and Richardson
Johnson and Johnson

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