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Generated: September 24, 2017

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Title: Methods for administration of antibiotics
Abstract:The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that does not result in muscle toxicity.
Inventor(s): Oleson, Jr.; Frederick B. (Concord, MA), Tally; Francis P. (Lincoln, MA)
Assignee: Cubist Pharmaceuticals, Incorporated (Lexington, MA)
Application Number:09/406,568
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International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hungary0103874► Subscribe
Hong Kong1040363► Subscribe
Spain2603086► Subscribe
European Patent Office1674107► Subscribe
Spain2259845► Subscribe
European Patent Office1115417► Subscribe91254Luxembourg► Subscribe
European Patent Office1115417► SubscribeCA 2006 00018Denmark► Subscribe
European Patent Office1115417► Subscribe300232Netherlands► Subscribe
European Patent Office1115417► Subscribe06C0022France► Subscribe
European Patent Office1115417► SubscribeSPC 018/2006Ireland► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving 500+ biopharmaceutical companies globally:

Cantor Fitzgerald
Boehringer Ingelheim
Fish and Richardson
Daiichi Sankyo
Harvard Business School

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