Phosphonocephem derivatives, process for the preparation of the same, and use thereof
A novel cephem compound of the formula: ##STR1## wherein R.sup.1 is a phosphono group or a group convertible to a phosphono group; R.sup.2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom or CH; Y is S, O or CH.sub.2 ; n is 0 or 1; one of R.sup.3 and R.sup.4 is a pyridinium group which may be substituted and the other is a hydrogen atom or hydrocarbon group which may be substituted, or R.sup.3 and R.sup.4 taken together may form a quaternalized nitrogen-containing heterocyclic ring which may be substituted, or its ester or its salt, which has a superior anti-bacterial activity, stability, absorbability, etc., a production thereof and a pharmaceutical composition containing it, is provided.
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