Details for Patent: 6,248,358

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Summary for Patent: 6,248,358

Title:	Bioadhesive progressive hydration tablets and methods of making and using the same
Abstract:	A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).
Inventor(s):	William J. Bologna, Howard L. Levine, Philippe Cartier, Dominique de Ziegler
Assignee:	Columbia Laboratories Bermuda Ltd , Juniper Pharmaceuticals Inc
Application Number:	US09/379,310
Patent Claim Types: see list of patent claims	Use; Composition; Delivery; Dosage form;

Drugs Protected by US Patent 6,248,358

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 6,248,358

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Argentina	016650
Argentina	032352
Argentina	036972
Argentina	043088
Austria	253892
Austria	306253
Australia	5582699