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Last Updated: February 7, 2023

Details for Patent: 6,221,633

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Summary for Patent: 6,221,633
Title: Insulin derivatives having a rapid onset of action
Abstract:The present invention relates to insulin derivatives which in comparison to human insulin, have an accelerated onset of action, to a process for their preparation and to their use, in particular in pharmaceutical preparations for the treatment of diabetes mellitus. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring amino acid residue, it optionally being possible for asparagine (Asn) in position 21 of the A chain to be replaced by Asp, Gly, Ser, Thr or Ala and for phenylalanine (Phe) in position B1 of the B chain and the amino acid residue in position B30 of the B chain to be absent.
Inventor(s): Ertl; Johann (Bremthal, DE), Habermann; Paul (Eppstein, DE), Geisen; Karl (Frankfurt, DE), Seipke; Gerhard (Hofheim, DE)
Assignee: Aventis Pharma Deutschland GmbH (Frankfurt am Main, DE)
Application Number:09/099,307
Patent Claim Types:
see list of patent claims
Compound; Process; Composition; Use; Formulation;

Drugs Protected by US Patent 6,221,633

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 6,221,633

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany197 26 167Jun 20, 1997

International Family Members for US Patent 6,221,633

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 015899 See Plans and Pricing
Austria 283919 See Plans and Pricing
Australia 7306498 See Plans and Pricing
Australia 740344 See Plans and Pricing
Brazil 9803708 See Plans and Pricing
Brazil PI9803708 See Plans and Pricing
Canada 2235443 See Plans and Pricing
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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