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Details for Patent: 6,221,633

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Patent 6,221,633 protects APIDRA and APIDRA SOLOSTAR and is included in one NDA.

This patent has thirty-eight patent family members in twenty-eight countries.

Summary for Patent: 6,221,633

Title: Insulin derivatives having a rapid onset of action
Abstract:The present invention relates to insulin derivatives which in comparison to human insulin, have an accelerated onset of action, to a process for their preparation and to their use, in particular in pharmaceutical preparations for the treatment of diabetes mellitus. In particular, the present invention relates to insulin derivatives or physiologically tolerable salts thereof in which asparagine (Asn) in position B3 of the B chain is replaced by a naturally occurring basic amino acid residue and at least one amino acid residue in the positions B27, B28 or B29 of the B chain is replaced by another naturally occurring amino acid residue, it optionally being possible for asparagine (Asn) in position 21 of the A chain to be replaced by Asp, Gly, Ser, Thr or Ala and for phenylalanine (Phe) in position B1 of the B chain and the amino acid residue in position B30 of the B chain to be absent.
Inventor(s): Ertl; Johann (Bremthal, DE), Habermann; Paul (Eppstein, DE), Geisen; Karl (Frankfurt, DE), Seipke; Gerhard (Hofheim, DE)
Assignee: Aventis Pharma Deutschland GmbH (Frankfurt am Main, DE)
Application Number:09/099,307
Patent Claim Types:
see list of patent claims
Compound; Process; Composition; Use; Formulation;
Patent Metrics:
Source: PatentQuant.com
Field: Biotechnology
Back Citations: 29th percentile
Forward Citations: 0th percentile

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Sanofi Aventis Us
APIDRA
insulin glulisine recombinant
INJECTABLE;IV (INFUSION), SUBCUTANEOUS021629-001Apr 16, 2004RXYes6,221,633► subscribeYY METHOD OF TREATING A PATIENT SUFFERING FROM DIABETES MELLITUS
Sanofi Aventis Us
APIDRA
insulin glulisine recombinant
INJECTABLE;IV (INFUSION), SUBCUTANEOUS021629-002Dec 20, 2005RXYes6,221,633► subscribeYY METHOD OF TREATING A PATIENT SUFFERING FROM DIABETES MELLITUS
Sanofi Aventis Us
APIDRA SOLOSTAR
insulin glulisine recombinant
INJECTABLE;SUBCUTANEOUS021629-003Feb 24, 2009RXNo6,221,633► subscribeYY METHOD OF TREATING A PATIENT SUFFERING FROM DIABETES MELLITUS
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Foreign Priority and PCT Information for Patent: 6,221,633

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany197 26 167Jun 20, 1997

International Patent Family for Patent: 6,221,633

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina015899► subscribe
Austria283919► subscribe
Australia7306498► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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