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Last Updated: November 18, 2019

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Details for Patent: 6,172,233

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Summary for Patent: 6,172,233
Title: Process for making paroxetine
Abstract:Compounds of structure (2) are prepared by reaction of an arecoline analogue of structure(4) with an organometallic compound containing an X-substituted phenyl group, such as a compound of structure (3). ##STR1## Suitably the compound of structure (3) is a Grignard reagent, where M is magnesium and Y is a halogen atom, or M may be a Group II metal and Y is a halogen atom or a second X-substituted phenyl group. When structure (3) is a Grignard reagent, the reaction is carried out either in a suitable non-ether solvent, typically a hydrocarbon or a non-reactive chlorinated hydrocarbon, or in a mixture of such a solvent with diethyl ether. Compounds of structure (2) are important intermediates in the preparation of inter alia paroxetine.
Inventor(s): Ward; Neal (Tonbridge, GB)
Assignee: SmithKline Beecham plc (Brentford, GB)
Application Number:09/007,475
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,172,233
Patent Claim Types:
see list of patent claims
Compound; Process;

Drugs Protected by US Patent 6,172,233

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 6,172,233

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9700690Jan 15, 1997

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