Details for Patent: 6,172,233

Summary for Patent: 6,172,233

Title:	Process for making paroxetine
Abstract:	Compounds of structure (2) are prepared by reaction of an arecoline analogue of structure(4) with an organometallic compound containing an X-substituted phenyl group, such as a compound of structure (3). ##STR1## Suitably the compound of structure (3) is a Grignard reagent, where M is magnesium and Y is a halogen atom, or M may be a Group II metal and Y is a halogen atom or a second X-substituted phenyl group. When structure (3) is a Grignard reagent, the reaction is carried out either in a suitable non-ether solvent, typically a hydrocarbon or a non-reactive chlorinated hydrocarbon, or in a mixture of such a solvent with diethyl ether. Compounds of structure (2) are important intermediates in the preparation of inter alia paroxetine.
Inventor(s):	Ward; Neal (Tonbridge, GB)
Assignee:	SmithKline Beecham plc (Brentford, GB)
Application Number:	09/007,475
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,172,233
Patent Claim Types: see list of patent claims	Compound; Process;

Drugs Protected by US Patent 6,172,233

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

Foreign Priority and PCT Information for Patent: 6,172,233

Foriegn Application Priority Data
Foreign Country	Foreign Patent Number	Foreign Patent Date
United Kingdom	9700690	Jan 15, 1997

International Family Members for US Patent 6,172,233

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
United Kingdom	9700690