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Last Updated: February 7, 2023

Details for Patent: 6,172,233

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Summary for Patent: 6,172,233
Title: Process for making paroxetine
Abstract:Compounds of structure (2) are prepared by reaction of an arecoline analogue of structure(4) with an organometallic compound containing an X-substituted phenyl group, such as a compound of structure (3). ##STR1## Suitably the compound of structure (3) is a Grignard reagent, where M is magnesium and Y is a halogen atom, or M may be a Group II metal and Y is a halogen atom or a second X-substituted phenyl group. When structure (3) is a Grignard reagent, the reaction is carried out either in a suitable non-ether solvent, typically a hydrocarbon or a non-reactive chlorinated hydrocarbon, or in a mixture of such a solvent with diethyl ether. Compounds of structure (2) are important intermediates in the preparation of inter alia paroxetine.
Inventor(s): Ward; Neal (Tonbridge, GB)
Assignee: SmithKline Beecham plc (Brentford, GB)
Application Number:09/007,475
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,172,233
Patent Claim Types:
see list of patent claims
Compound; Process;

Drugs Protected by US Patent 6,172,233

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 6,172,233

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9700690Jan 15, 1997

International Family Members for US Patent 6,172,233

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
United Kingdom 9700690 See Plans and Pricing
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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Serving leading biopharmaceutical companies globally:

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