Details for Patent: 6,103,219

Summary for Patent: 6,103,219

Title:	Pharmaceutical excipient having improved compressibility
Abstract:	A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
Inventor(s):	Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
Assignee:	J Rettenmaier and Soehne GmbH and Co KG
Application Number:	US08/992,073
Patent Claim Types: see list of patent claims	Use; Composition; Formulation; Process; Dosage form;

Drugs Protected by US Patent 6,103,219

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 6,103,219

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	239450
Austria	441403
Austria	445391
Australia	4759896