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Serving hundreds of leading biopharmaceutical companies globally:

Citi
Moodys
Farmers Insurance
UBS
Johnson and Johnson
Express Scripts
US Department of Justice
Federal Trade Commission
Boehringer Ingelheim

Generated: April 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,028,071

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Which drugs does patent 6,028,071 protect, and when does it expire?

Patent 6,028,071 protects FOLOTYN and is included in one NDA.

This patent has twelve patent family members in nine countries.
Summary for Patent: 6,028,071
Title: Purified compositions of 10-propargyl-10-deazaaminopterin and methods of using same in the treatment of tumors
Abstract:Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.
Inventor(s): Sirotnak; Francis M. (New York, NY), Piper; James R. (Birmingham, AL), DeGraw; Joseph I. (Missoula, MT), Colwell; William T. (Menlo Park, CA)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY) SRI International (Menlo Park, CA) Southern Research Institute (Birmingham, AL)
Application Number:09/214,984
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 6,028,071

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Allos FOLOTYN pralatrexate SOLUTION;INTRAVENOUS 022468-001 Sep 24, 2009 RX Yes No ➤ Try a Free Trial ➤ Try a Free Trial Y Y TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA ➤ Try a Free Trial
Allos FOLOTYN pralatrexate SOLUTION;INTRAVENOUS 022468-002 Sep 24, 2009 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y Y TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 6,028,071

PCT Information
PCT FiledJuly 16, 1997PCT Application Number:PCT/US97/11982
PCT Publication Date:January 22, 1998PCT Publication Number: WO98/02163

Non-Orange Book US Patents Family Members for Patent 6,028,071

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,323,205 Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 6,028,071

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Japan 5271677 ➤ Try a Free Trial
Japan 2009091361 ➤ Try a Free Trial
Spain 2313737 ➤ Try a Free Trial
European Patent Office 2258702 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Cipla
US Department of Justice
Boehringer Ingelheim
Daiichi Sankyo
Accenture
Cantor Fitzgerald
Federal Trade Commission
Deloitte

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