Details for Patent: 5,972,882

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Summary for Patent: 5,972,882

Title:	Treatment of polycystic kidney disease using vasopressin V.sub.2 receptor antagonists
Abstract:	The present invention is directed to the novel treatment of ARPKD and ADPKD by administering a pharmacologically effective amount of a V.sub.2 receptor antagonist. Orally active V.sub.2 receptor antagonists such as OPC-31260, OPC-41061, SR121463A and VPA-985 are administered alone, or in combination to mammalian PKD subjects to reduce the cAMP generated by the increased expression of AVP-V.sub.2 receptor, AQP2 and AQP3, thereby reducing and/or preventing cyst enlargement.
Inventor(s):	Gattone, II; Vincent H. (Overland Park, KS)
Assignee:	University of Kansas Medical Center (Kansas City, KS)
Application Number:	09/211,396
Patent Claim Types: see list of patent claims	Use; Delivery;

Drugs Protected by US Patent 5,972,882

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

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