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|Title:||Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal|
|Abstract:||The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have growth-inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to mammals. The antagonists may be used to reduce the activity of growth hormone in a mammal, especially one suffering from diabetes, diabetic retinopathy, diabetic nephropathy, a growth hormone secreting tumor, acromegaly, or gigantism.|
|Inventor(s):||Kopchick; John J. (Athens, OH), Chen; Wen Y. (Athens, OH)|
|Assignee:||Ohio University/Edison Biotechnology Institute (Athens, OH)|
Patent Claim Types:|
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|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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