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Last Updated: April 24, 2024

Details for Patent: 5,935,946

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Summary for Patent: 5,935,946

Title:	Nucleotide analog composition and synthesis method
Abstract:	The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.
Inventor(s):	Munger, Jr.; John D. (Alviso, CA), Rohloff; John C. (Mountain View, CA), Schultze; Lisa M. (San Carlos, CA)
Assignee:	Gilead Sciences, Inc. (Foster City, CA)
Application Number:	08/900,752
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 5,935,946
Patent Claim Types: see list of patent claims	Composition; Compound; Formulation; Use; Dosage form; Process;

Drugs Protected by US Patent 5,935,946

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

International Family Members for US Patent 5,935,946

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	228526	⤷ Try a Trial
Austria	288914	⤷ Try a Trial
Austria	305009	⤷ Try a Trial
Australia	756793	⤷ Try a Trial
Australia	8582798	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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