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Generated: November 20, 2017

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Details for Patent: 5,880,106

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Summary for Patent: 5,880,106

Title: Oral dosing formulations of dideoxy purine nucleosides
Abstract:Improved oral dosage formulations for acid-labile dideoxy purine nucleoside derivatives such as ddA, ddI, and ddG, have been developed by incorporating selected water-insoluble buffering systems in the formulation. These novel formulations provide reduced mass dosage units in the form of convenient, palatable chewable/dispersible tablets or a dry powder sachet. The reduced mass requirement, necessary to allow tablets of reasonable size, was achieved in part by an unexpected 20 to 25% increase in drug bioavailability resulting from use of the selected buffering systems comprised of an insoluble magnesium antacid agent and either dihydroxyaluminum sodium carbonate or calcium carbonate.
Inventor(s): Ullah; Ismat (Cranbury, NJ), Agharkar; Shreeram Narahari (Princeton, NJ), Wiley; Gary James (Jackson, NJ)
Assignee: Bristol-Myers Squibb Company (Princeton, NJ)
Application Number:08/942,660
Patent Claim Types:
see list of patent claims
Composition; Delivery; Formulation; Compound; Dosage form;

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