Details for Patent: 5,808,146

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Which drugs does patent 5,808,146 protect, and when does it expire?

Patent 5,808,146 protects AXUMIN and is included in one NDA.

This patent has ten patent family members in five countries.

Summary for Patent: 5,808,146

Title:	Amino acid analogs for tumor imaging
Abstract:	The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes including fluorine-18, iodine-123, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77 and bromine-82. In one aspect, the invention features amino acid compounds that have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds show a target to non-target ratio of at least 5:1, are stable in vivo and substantially localized to target within 1 hour after administration. An especially preferred amino acid compound is [.sup.18 F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC). In another aspect, the invention features pharmaceutical compositions comprised of an .alpha.-amino acid moiety attached to either a four, five, or a six member carbon-chain ring. In addition, the invention features analogs of .alpha.-aminoisobutyric acid.
Inventor(s):	Goodman; Mark M. (Atlanta, GA), Shoup; Timothy (Decatur, GA)
Assignee:	Emory University (Atlanta, GA)
Application Number:	08/554,906
Prior Art and Litigation Support	Order Prior Art and Litigation support for Patent 5,808,146
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 5,808,146

Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Blue Earth	AXUMIN	fluciclovine f-18	SOLUTION;INTRAVENOUS	208054-001	May 27, 2016		RX	Yes	Yes	➤ Sign Up	➤ Sign Up		Y			➤ Sign Up
Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 5,808,146

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	1120497	➤ Sign Up
Australia	720738	➤ Sign Up
Canada	2237218	➤ Sign Up
European Patent Office	0862464	➤ Sign Up
Japan	2000500442	➤ Sign Up
Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration

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