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Last Updated: March 28, 2024

Details for Patent: 5,767,285


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Summary for Patent: 5,767,285
Title: Linkers useful for the synthesis of conjugates of methyltrithio antitumor agents
Abstract:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Inventor(s): Hamann; Philip Ross (Garnerville, NY), Hinman; Lois (N. Tarrytown, NY), Hollander; Irwin (Monsey, NY), Holcomb; Ryan (Glen Rock, NJ), Hallett; William (New City, NY), Tsou; Hwei-Ru (New City, NY), Weiss; Martin J. (Ft. Lee, NJ)
Assignee: American Cyanamid Company (Madison, NJ)
Application Number:08/462,939
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 5,767,285

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 5,767,285

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 223234 ⤷  Try a Trial
Australia 2044995 ⤷  Try a Trial
Australia 697280 ⤷  Try a Trial
Brazil 1100941 ⤷  Try a Trial
Brazil 1100990 ⤷  Try a Trial
Brazil 1101078 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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