|Title:||Therapeutic process for the treatment of the pathologies of type II diabetes|
|Abstract:||A process for the long term modification and regulation of lipid and carbohydrate metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes)--by administration (i.e., by oral, sublingual or parenternal administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.|
|Inventor(s):||Cincotta; Anthony H. (Andover, MA), Meier; Albert H. (Baton Rouge, LA)|
|Assignee:||The Board of Supervisors of Louisiana State University and Agricultural (Baton Rouge, LA)|
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