Details for Patent: 5,750,497
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Summary for Patent: 5,750,497
Title: | Acylated insulin |
Abstract: | The present invention relates to human insulin derivatives having a protracted profile of action in which the A21 and B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; Phe.sup.B1 may be deleted; the B30 amino acid residue is (a) a non-codable, lipophilic amino acid having from 10 to 24 carbon atoms in which case an acyl group of a carboxylic acid with up to 5 carbon atoms is bound to the E-amino group of Lys.sup.B29 ; (b) any amino acid residue which can be coded by the genetic code except Lys, Arg and Cys, in which case a lipophilic substituent is bound to the E-amino group of Lys.sup.B29 ; or (c) deleted, in which case a lipophilic substituent is bound to the E-amino group of LyS.sup.B29 ; and any Zn.sup.2+ complexes thereof; provided that when the B30 amino acid residue is Thr or Ala, the A21 and B3 amino acid residues are both Asn and Phe.sup.B1 is present, then the insulin derivative is a Zn.sup.2 + complex. |
Inventor(s): | Havelund; Svend (Bagsv.ae butted.rd, DK), Halstr.o slashed.m; John (Hundested, DK), Jonassen; Ib (Valby, DK), Andersen; Asser Sloth (Frederiksberg C, DK), Markussen; Jan (Herlev, DK) |
Assignee: | Novo Nordisk A/S (Bagsvaerd, DK) |
Application Number: | 08/400,256 |
Patent Claim Types: see list of patent claims | Compound; Composition; Formulation; Use; |
Drugs Protected by US Patent 5,750,497
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 5,750,497
Foriegn Application Priority Data | ||
Foreign Country | Foreign Patent Number | Foreign Patent Date |
Denmark | 1044/93 | Sep 17, 1993 |
International Family Members for US Patent 5,750,497
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Austria | 204882 | ⤷ Try a Trial | |||
Australia | 4846197 | ⤷ Try a Trial | |||
Australia | 682061 | ⤷ Try a Trial | |||
Australia | 7652094 | ⤷ Try a Trial | |||
Bulgaria | 100420 | ⤷ Try a Trial | |||
Bulgaria | 61611 | ⤷ Try a Trial | |||
Brazil | 9407508 | ⤷ Try a Trial | |||
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