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|Title:||Biodegradable in-situ forming implants and methods of producing the same|
|Abstract:||A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.|
|Inventor(s):||Dunn; Richard L. (Fort Collins, CO), English; James P. (Birmingham, AL), Cowsar; Donald R. (Birmingham, AL), Vanderbilt; David P. (Birmingham, AL)|
|Assignee:||Atrix Laboratories, Incorporated (Fort Collins, CO)|
Patent Claim Types:|
see list of patent claims
|Use; Device; Composition; Formulation; Delivery;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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