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US Army
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Generated: July 18, 2018

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Details for Patent: 5,723,606

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Summary for Patent: 5,723,606
Title: Condensed benzazepine derivative and pharmaceutical composition thereof
Abstract:This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group, A: a single bond; a group represented by the formula n: 0 or an integer of from 1 to 3, R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.4 may together form a lower alkylene group having 2 to 7 carbon atoms), and ring C: a benzene ring which may optionally have substituent(s)) and salts thereof; to pharmaceutical compositions which contain these compounds as an active ingredient and to intermediates which are useful in synthesizing these compounds. The compounds of this invention are useful as arginine vasopressin antagonists.
Inventor(s): Tanaka; Akihiro (Ibaraki, JP), Koshio; Hiroyuki (Ibaraki, JP), Taniguchi; Nobuaki (Ibaraki, JP), Matsuhisa; Akira (Ibaraki, JP), Sakamoto; Ken-ichiro (Ibaraki, JP), Yamazaki; Atsuki (Ibaraki, JP), Yatsu; Takeyuki (Ibaraki, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:08/586,686
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,723,606

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Cumberland Pharms VAPRISOL conivaptan hydrochloride INJECTABLE;IV (INFUSION) 021697-001 Dec 29, 2005 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA ➤ Try a Free Trial
Cumberland Pharms VAPRISOL conivaptan hydrochloride INJECTABLE;IV (INFUSION) 021697-001 Dec 29, 2005 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH EUVOLEMIC HYPONATREMIA ➤ Try a Free Trial
Cumberland Pharms VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER conivaptan hydrochloride INJECTABLE;IV (INFUSION) 021697-002 Oct 8, 2008 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA ➤ Try a Free Trial
Cumberland Pharms VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER conivaptan hydrochloride INJECTABLE;IV (INFUSION) 021697-002 Oct 8, 2008 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH EUVOLEMIC HYPONATREMIA ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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Foreign Priority and PCT Information for Patent: 5,723,606

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan5-180435Jul 21, 1993
PCT Information
PCT FiledJuly 19, 1994PCT Application Number:PCT/JP94/01183
PCT Publication Date:February 02, 1995PCT Publication Number: WO95/03305

Non-Orange Book US Patents Family Members for Patent 5,723,606

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,856,564 Condensed benzazepine derivative and pharmaceutical composition thereof ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Family Members for US Patent 5,723,606

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 239726 ➤ Try a Free Trial
Austria 277003 ➤ Try a Free Trial
Australia 3990697 ➤ Try a Free Trial
Australia 683483 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Merck
US Army
Argus Health
US Department of Justice
Accenture
McKinsey
Fuji
Julphar
Federal Trade Commission

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