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Last Updated: November 22, 2019

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Details for Patent: 5,723,606

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Summary for Patent: 5,723,606
Title: Condensed benzazepine derivative and pharmaceutical composition thereof
Abstract:This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group, A: a single bond; a group represented by the formula n: 0 or an integer of from 1 to 3, R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.4 may together form a lower alkylene group having 2 to 7 carbon atoms), and ring C: a benzene ring which may optionally have substituent(s)) and salts thereof; to pharmaceutical compositions which contain these compounds as an active ingredient and to intermediates which are useful in synthesizing these compounds. The compounds of this invention are useful as arginine vasopressin antagonists.
Inventor(s): Tanaka; Akihiro (Ibaraki, JP), Koshio; Hiroyuki (Ibaraki, JP), Taniguchi; Nobuaki (Ibaraki, JP), Matsuhisa; Akira (Ibaraki, JP), Sakamoto; Ken-ichiro (Ibaraki, JP), Yamazaki; Atsuki (Ibaraki, JP), Yatsu; Takeyuki (Ibaraki, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:08/586,686
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,723,606

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Cumberland Pharms VAPRISOL conivaptan hydrochloride INJECTABLE;INTRAVENOUS 021697-001 Dec 29, 2005 DISCN No No   Start Trial   Start Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH EUVOLEMIC HYPONATREMIA   Start Trial
Cumberland Pharms VAPRISOL conivaptan hydrochloride INJECTABLE;INTRAVENOUS 021697-001 Dec 29, 2005 DISCN No No   Start Trial   Start Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA   Start Trial
Cumberland Pharms VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER conivaptan hydrochloride INJECTABLE;INTRAVENOUS 021697-002 Oct 8, 2008 RX Yes Yes   Start Trial   Start Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH EUVOLEMIC HYPONATREMIA   Start Trial
Cumberland Pharms VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER conivaptan hydrochloride INJECTABLE;INTRAVENOUS 021697-002 Oct 8, 2008 RX Yes Yes   Start Trial   Start Trial Y Y METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,723,606

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan5-180435Jul 21, 1993
PCT Information
PCT FiledJuly 19, 1994PCT Application Number:PCT/JP94/01183
PCT Publication Date:February 02, 1995PCT Publication Number: WO95/03305

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Serving leading biopharmaceutical companies globally:

Medtronic
Dow
Johnson and Johnson
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Boehringer Ingelheim
Mallinckrodt

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