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Details for Patent: 5,723,606

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Patent 5,723,606 protects VAPRISOL and VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER and is included in one NDA.

This patent has twenty-nine patent family members in seventeen countries.

Summary for Patent: 5,723,606

Title: Condensed benzazepine derivative and pharmaceutical composition thereof
Abstract:This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group, A: a single bond; a group represented by the formula n: 0 or an integer of from 1 to 3, R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.4 may together form a lower alkylene group having 2 to 7 carbon atoms), and ring C: a benzene ring which may optionally have substituent(s)) and salts thereof; to pharmaceutical compositions which contain these compounds as an active ingredient and to intermediates which are useful in synthesizing these compounds. The compounds of this invention are useful as arginine vasopressin antagonists.
Inventor(s): Tanaka; Akihiro (Ibaraki, JP), Koshio; Hiroyuki (Ibaraki, JP), Taniguchi; Nobuaki (Ibaraki, JP), Matsuhisa; Akira (Ibaraki, JP), Sakamoto; Ken-ichiro (Ibaraki, JP), Yamazaki; Atsuki (Ibaraki, JP), Yatsu; Takeyuki (Ibaraki, JP)
Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:08/586,686
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Cumberland Pharms
VAPRISOL
conivaptan hydrochloride
INJECTABLE;IV (INFUSION)021697-001Dec 29, 2005DISCNNo5,723,606► subscribeYY METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA
Cumberland Pharms
VAPRISOL
conivaptan hydrochloride
INJECTABLE;IV (INFUSION)021697-001Dec 29, 2005DISCNNo5,723,606► subscribeYY METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATEINTS WITH EUVOLEMIC HYPONATREMIA
Cumberland Pharms
VAPRISOL IN 5% DEXTROSE IN PLASTIC CONTAINER
conivaptan hydrochloride
INJECTABLE;IV (INFUSION)021697-002Oct 8, 2008RXYes5,723,606► subscribeYY METHOD OF USING ANTAGONIST OF ARGININE VASOPRESSIN (AVA) V1A AND V2 RECEPTORS FOR INTRAVENOUS TREATMENT OF PATIENTS WITH HYPERVOLEMIC HYPONATREMIA
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Foreign Priority and PCT Information for Patent: 5,723,606

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan5-180435Jul 21, 1993
PCT Information
PCT FiledJuly 19, 1994PCT Application Number:PCT/JP94/01183
PCT Publication Date:February 02, 1995PCT Publication Number: WO95/03305

Non-Orange Book Patents for Patent: 5,723,606

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,856,564 Condensed benzazepine derivative and pharmaceutical composition thereof► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 5,723,606

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria239726► subscribe
Austria277003► subscribe
Australia3990697► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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