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Details for Patent: 5,654,010

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Summary for Patent: 5,654,010

Title: Composition for sustained release of human growth hormone
Abstract:A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, stabilized hGH, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active hGH, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, stabilized hGH in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said hGH particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated hGH in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention. The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
Inventor(s): Johnson; OluFunmi Lily (Cambridge, MA), Ganmukhi; Medha M. (Wexford, PA), Bernstein; Howard (Cambridge, MA), Auer; Henry (Belmont, MA), Khan; M. Amin (Dowington, PA)
Assignee: Alkermes, Inc. (Cambridge, MA)
Application Number:08/473,544
Patent Claim Types:
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Composition; Use;

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Premature patent expiration for: 5,654,010

Expiration due to failure to pay maintenance fee

Patent Number Expiration Date
5,654,010 August 05, 2009

International Patent Family for Patent: 5,654,010

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria195652<disabled in preview>
Austria204468<disabled in preview>
Austria222500<disabled in preview>
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