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Generated: August 18, 2017

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Title: Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
Abstract:Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and: (a) A is 3.alpha.-(6.beta., 7.beta.-epoxy)-tropanyl methobromide and R.sub.1 is 2-thienyl; (b) A is 3.alpha.-(6, 7dehydro)-tropanyl methobromide and R.sub.1 is 2-thienyl; (c) A is 3.beta.-tropanyl methobromide and R.sub.1 is 2-thienyl; and, (d) A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide and R.sub.1 is cyclopentyl. These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.
Inventor(s): Banholzer; Rolf (Ingelheim am Rheim, DE), Bauer; Rudolf (Wiesbaden, DE), Reichl; Richard (Ingelheim am Rheim, DE)
Assignee: Boehringer Ingelheim GmbH (Ingelheim am Rhein, DE)
Application Number:08/405,111
Patent Claim Types:
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Compound; Use; Composition; Dosage form;

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Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany39 31 041.8Sep 16, 1989

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Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
CroatiaP940723► Subscribe
Hungary9200857► Subscribe
HungaryT60740► Subscribe
Hungary208823► Subscribe
Hungary210612► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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