Triacetin as a penetration enhancer for transdermal delivery of a basic drug
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pK.sub.a of about 8.0 or greater, an effective amount of penetration enhancer consisting essentially of triacetin, and a polymer later preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.
Quan; Danyi (Salt Lake City, UT), Deshpanday; Ninad A. (Salt Lake City, UT), Venkateshwaran; Srinivasan (Salt Lake City, UT), Ebert; Charles D. (Salt Lake City, UT)
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