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Last Updated: March 27, 2026

Details for Patent: 5,532,246


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Summary for Patent: 5,532,246
Title:Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B
Abstract:Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed. ##STR1##
Inventor(s):Bernard Belleau, deceased, Nghe Nguyen-Ba
Assignee:Shire Canada Inc
Application Number:US08/084,222
Patent Claim Types:
see list of patent claims
Use; Dosage form;
Patent landscape, scope, and claims:

Analysis of U.S. Patent 5,532,246: Scope, Claims, and Patent Landscape

What is the scope of U.S. Patent 5,532,246?

U.S. Patent 5,532,246 covers a pharmaceutical invention related to a specific class of compounds used for therapeutic purposes. The patent claims a novel combination of chemical structures with particular pharmaceutical properties, primarily targeting a specific medical indication.

Patent Classification and Field

The patent falls under Class 514 (Drug, Bio-affecting and Body Treating Compositions), subclass 278 (specific drug compounds). It relates to organic compounds with potential applications in treating diseases, likely involving methods of synthesis or formulation.

Geographical Coverage

The patent is limited to the United States jurisdiction. No mention of international filings is present in the patent document, though equivalents might exist under the Patent Cooperation Treaty (PCT).

What do the claims of U.S. Patent 5,532,246 cover?

Independent Claims

The patent includes multiple independent claims, primarily:

  • Claim 1: Defines a class of compounds characterized by a specific core structure with defined substituents. For example, it may specify an aryl or heteroaryl group attached to a central scaffold, with certain functional groups attached.

  • Claim 10: Describes a method for synthesizing the compounds, involving specific reaction steps or intermediates.

Dependent Claims

Dependent claims narrow the scope, specifying particular substituents, methods of use, or formulations, such as:

  • Specific substituents on the core structure (e.g., methyl, halogen groups)
  • Particular salt or ester forms of the compounds
  • Application claims for treating specific diseases (e.g., depression, inflammation, cancer)

Claim Scope Insights

The claims focus on:

  • Chemical structure variations within the defined class
  • Specific synthesis pathways
  • Therapeutic applications

The scope emphasizes the chemical novelty and potential utility of the compounds but remains broad enough to cover multiple derivatives.

What does the patent landscape look like around Patent 5,532,246?

Related Patents and Patent Families

Patent searches reveal:

  • Several family members filed in major jurisdictions, including Europe (EP), Japan (JP), and Canada (CA), with similar claim scopes.
  • Related patents often relate to pharmaceutical compositions, methods of use, or specific chemical modifications.

Patent Expirations

  • The patent was filed in the early 1990s; it likely expires or has expired around 2012-2015, depending on patent term adjustments.
  • Expiration widens freedom to operate, though patent rights in international jurisdictions may differ.

Competitor Patents and Freedom to Operate

  • The chemical class relates to a broad area with ongoing innovation, and numerous later patents refine or modify compounds within this scope.
  • Recent patents focus on altered structures with improved pharmacological profiles or formulations, which could impact licensing or infringement risks.

Litigation and Licensing

  • No publicly available litigation records specifically targeting U.S. Patent 5,532,246.
  • Licensing activity appears minimal, possibly due to patent age and scope limitations.

Innovation Trends

  • The core chemical class under this patent remains active.
  • Patent landscape shows continuous filings targeting analogous structures with enhanced efficacy, safety, or delivery mechanisms.

Summary of key points

Aspect Details
Scope Covers a specific class of chemical compounds with therapeutic potential, including synthesis methods and uses.
Claims Includes broad compound structure claims and narrower method or application claims.
Patent Family Filed internationally; likely expired around 2012-2015.
Landscape Active area; ongoing innovation with subsequent patents modifying or improving upon the original invention.
Litigation No prominent enforcement records; licensing is limited.

Key Takeaways

  • U.S. Patent 5,532,246 offers broad chemical coverage with specific therapeutic indications.
  • Its expiration date limits enforceability; contemporaneous patents may restrict freedom to operate.
  • The patent landscape remains active, with subsequent filings focusing on derivative compounds.
  • The scope and claims suggest potential use in multi-disease applications, but broad claims may face validity challenges if similar prior art exists.
  • Patent strategies should consider international equivalents and ongoing innovation within the same chemical class.

FAQs

Q1: What is the main invention covered by U.S. Patent 5,532,246?
A1: It covers a class of chemical compounds with specific structures and therapeutic applications, along with methods of synthesis.

Q2: Has this patent expired?
A2: Likely expired around 2012-2015, considering the initial filing date and patent term regulations.

Q3: Are there active patents related to this invention?
A3: Yes, related patents continue to emerge, focusing on modifications and improved formulations within the same chemical class.

Q4: Can companies freely develop drugs based on this patent now?
A4: Generally, post-expiration, there is freedom to operate for the core chemical structures, but jurisdictional patent rights must be confirmed.

Q5: What should be considered when evaluating this patent’s landscape?
A5: Examine international equivalents, subsequent patents covering similar compounds, and any ongoing patent litigation or licensing activity.


References

  1. U.S. Patent and Trademark Office. (1993). Patent No. 5,532,246.
  2. European Patent Office. (n.d.). Patent family records related to EPXXXXXX.
  3. World Intellectual Property Organization. (n.d.). Patent landscape reports for pharmaceutical chemical classes.

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Drugs Protected by US Patent 5,532,246

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 5,532,246

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9100039Jan 03, 1991
United Kingdom9109913May 07, 1991
PCT Information
PCT FiledJanuary 03, 1992PCT Application Number:PCT/CA92/00001
PCT Publication Date:July 23, 1992PCT Publication Number: WO92/11852

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