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Serving leading biopharmaceutical companies globally:

Cipla
US Army
Chinese Patent Office
Teva
Colorcon
McKesson
Novartis
Julphar
Medtronic
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Generated: January 17, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,500,413

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Summary for Patent: 5,500,413
Title: Process for manufacture of 1-deamino-8-D-arginine vasopressin
Abstract:A process for the manufacture of 1-deamino-8-D-arginine vasopressin (DDAVP) comprising, condensing a preparation of Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-OH (SEQ ID NO: 1), where R.sup.1 and R.sup.2 are sulfhydryl-protecting groups, with the dipeptide (R.sup.3)-D-Arg(HCl)-Gly-NH.sub.2, where R.sup.3 is an acid-sensitive amino-protecting group, to form Mpa(R.sup.1)-Tyr-Phe-Gln-Asn-Cys(R.sup.2)-Pro-D-Arg(HCl)-Gly-NH.sub.2 (SEQ ID NO: 1), which is oxidized with iodine in a protic solvent. The reaction mixture containing the oxidized product can be purified by ion exchange chromatography on a cation exchange resin equilibrated with acid. Also disclosed is high-purity DDAVP obtained by this process and its use for treating diurea.
Inventor(s): Larsson; Krister (Malmo, SE), Mellbrand; Thomas (Malmo, SE), Mornstam; Birgitta (Malmo, SE), Roschester; Jan (Lund, SE), Skoldback; Jan-Ake (Malmo, SE)
Assignee: Ferring AB (Malmo, SE)
Application Number:08/084,847
Patent Claim Types:
see list of patent claims
Use; Compound;

Drugs Protected by US Patent 5,500,413

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,500,413

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 0710247 ➤ Subscribe
China 1125952 ➤ Subscribe
China 1040648 ➤ Subscribe
Germany 69427985 ➤ Subscribe
Denmark 0710247 ➤ Subscribe
Canada 2166297 ➤ Subscribe
Austria 204296 ➤ Subscribe
Spain 2159562 ➤ Subscribe
Greece 3036935 ➤ Subscribe
Hong Kong 1000910 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Julphar
Accenture
Express Scripts
Moodys
US Department of Justice
Deloitte
AstraZeneca
McKesson
Fish and Richardson

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