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|Title:||Growth hormone antagonists|
|Abstract:||The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have growth inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist. Animals have been made which exhibited a reduced growth phenotype.|
|Inventor(s):||Kopchick; John J. (Athens, OH), Chen; Wen Y. (Athens, OH)|
|Assignee:||Ohio University (Athens, OH)|
Patent Claim Types:|
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|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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