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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Medtronic
Express Scripts
Citi
Covington
Teva
Fish and Richardson
QuintilesIMS
Harvard Business School

Generated: April 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,344,656

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Summary for Patent: 5,344,656
Title: Subsaturated transdermal therapeutic system having improved release characteristics
Abstract:Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer. The devices are usable to deliver agents which are liquid at body temperatures such as benztropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol, for example.
Inventor(s): Enscore; David J. (Sunnyvale, CA), Campbell; Patricia S. (Palo Alto, CA), Osborne; James L. (Mountain View, CA), Smart; Melinda K. (Sunnyvale, CA), Yum; Su I. (Los Altos, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:08/078,540
Patent Claim Types:
see list of patent claims
Delivery; Device; Use;

Drugs Protected by US Patent 5,344,656

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,344,656

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Ireland 81102 ➤ Try a Free Trial
Australia 3852189 ➤ Try a Free Trial
Australia 3913695 ➤ Try a Free Trial
Australia 8585291 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Citi
McKesson
Baxter
Mallinckrodt
Cerilliant
QuintilesIMS
Harvard Business School
Accenture
Cipla

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