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|Title:||Controlled release oxycodone compositions|
|Abstract:||A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of oxycodone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37.degree. C. is between 12.5% and 42.5% (by weight) oxycodone released after 1 hour, between 25% and 55% (by weight) oxycodone released after 2 hours, between 45% and 75% (by weight) oxycodone released after 4 hours and between 55% and 85% (by weight) oxycodone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of oxycodone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.|
|Inventor(s):||Oshlack; Benjamin (New York, NY), Minogue; John J. (Mount Vernon, NY), Chasin; Mark (Manalpan, NJ)|
|Assignee:||Euroceltique, S.A. (LU)|
Patent Claim Types:|
see list of patent claims
|Formulation; Compound; Dosage form; Composition; Process;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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