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|Title:||Preparation of homogeneous hydrogel copolymers|
|Abstract:||A method is provided for the preparation of homogeneous copolymers having a redetermined equilibrium water content (EWC) value formed by the addition polymerization of a mixture of ethylenically unsaturated monomer A and ethylenically unsaturated monomer B, for example, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The method requires determining the EWC values of the hydrogel homopolymer of hydrophilic monomer A (homopolymer A) and the hydrogel homopolymer of hydrophilic monomer B (homopolymer B); determining the relationship of the EWC values of the homogeneous copolymers AB versus the chemical composition of said copolymers AB; selecting the targeted EWC value and determining the chemical composition of copolymer AB having the targeted EWC value; forming a polymerizable mixture of monomer A and monomer B in amounts sufficient to yield copolymer AB having the targeted EWC value; and effect the polymerization reaction to yield copolymer AB characterized by the targeted EWC value. A method is also provided for the preparation of a delivery device including a drug contained in the reservoir of the hydrogel of copolymer AB, said device being characterized by its capability of eluting or releasing the drug through the hydrogel membrane to a delivery environment at a predetermined rate. There is also disclosed a sterilized kit containing a trocar or hypodermic needle/syringe and the aforesaid drug delivery device having a cylindrical shape with a rounded or bullet-like extremity.|
|Inventor(s):||Kuzma; Petr (Monmouth Junction, NJ), Moro; Daniel G. (Randolph, NJ), Quandt; Harry (North Middletown, NJ)|
|Assignee:||Hydro Med Science Division of National Patent Development Corp. (New York, NY)|
Patent Claim Types:|
see list of patent claims
|Use; Composition; Delivery; Device;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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