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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
Cerilliant
Colorcon
Moodys
Covington
Citi
Cantor Fitzgerald
McKinsey
AstraZeneca

Generated: August 15, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,250,534

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Summary for Patent: 5,250,534
Title: Pyrazolopyrimidinone antianginal agents
Abstract:Compounds of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl)C.sub.1 -C.sub.6 alkyl; R.sup.4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, morpholino, or 4-N-(R.sup.6)-piperazinyl group; R.sup.5 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, NR.sup.7 R.sup.8, or CONR.sup.7 R.sup.8 ; R.sup.6 is H, C.sub.1 -C.sub.6 alkyl, (C.sub.1 -C.sub.3 alkoxy) C.sub.2 - C.sub.6 alkyl, hydroxy C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 N)C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 NCO)C.sub.1 -C.sub.6 alkyl, CONR.sup.7 R.sup.8, CSNR.sup.7 R.sup.8 or C(NH)NR.sup.7 R.sup.8 ; R.sup.7 and R.sup.8 are each independently H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkoxy)C.sub.2 -C.sub.4 alkyl or hydroxy C.sub.2 -C.sub.4 alkyl; and pharmaceutically acceptable salts thereof, are selective cGMP PDE inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.
Inventor(s): Bell; Andrew S. (Groton, CT), Brown; David (Groton, CT), Terrett; Nicholas K. (Groton, CT)
Assignee: Pfizer Inc. (New York, NY)
Application Number:07/882,988
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,250,534
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 5,250,534

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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Foreign Priority and PCT Information for Patent: 5,250,534

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom9013750Jun 20, 1990

International Family Members for US Patent 5,250,534

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hungary 211646 ➤ Try a Free Trial
European Patent Office 0463756 ➤ Try a Free Trial 300048 Netherlands ➤ Try a Free Trial
European Patent Office 0463756 ➤ Try a Free Trial SPC/GB99/004 United Kingdom ➤ Try a Free Trial
European Patent Office 0463756 ➤ Try a Free Trial 99C0007 Belgium ➤ Try a Free Trial
European Patent Office 0463756 ➤ Try a Free Trial C990005 Netherlands ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

McKesson
US Army
Express Scripts
Moodys
Deloitte
Chubb
Harvard Business School
Argus Health
AstraZeneca

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