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Serving hundreds of leading biopharmaceutical companies globally:

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Baxter
Johnson and Johnson
Harvard Business School
Daiichi Sankyo

Generated: May 27, 2018

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Details for Patent: 5,219,554

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Summary for Patent: 5,219,554
Title: Hydrated biodegradable superparamagnetic metal oxides
Abstract:This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.
Inventor(s): Groman; Ernest V. (Brookline, MA), Josephson; Lee (Arlington, MA), Lewis; Jerome M. (Newton, MA)
Assignee: Advanced Magnetics, Inc. (Cambridge, MA)
Application Number:07/863,360
Patent Claim Types:
see list of patent claims
Formulation; Compound;

Drugs Protected by US Patent 5,219,554

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Austria 135920 ➤ Try a Free Trial
Austria 139431 ➤ Try a Free Trial
Austria 142891 ➤ Try a Free Trial
Austria 143604 ➤ Try a Free Trial
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Serving hundreds of leading biopharmaceutical companies globally:

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Boehringer Ingelheim
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Federal Trade Commission
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