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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
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Medtronic
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Daiichi Sankyo

Generated: January 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,202,333

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Summary for Patent: 5,202,333
Title: Tricyclic 5-HT.sub.3 receptor antagonists
Abstract:The present invention is directed to 5-HT.sub.3 receptor antagonist compounds of formula I: ##STR1## in which the dashed line denotes an optional double bond; n is 1, 2 or 3; p is 0, 1, 2 or 3; q is 0, 1 or 2; each R.sup.1 is independently selected from halogen, hydroxy, lower alkoxy, lower alkyl, nitro, amino, amino carbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino; each R.sup.2 is lower alkyl; and R.sup.3 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## in which u is 0 or 1; z is 1, 2 or 3; and R.sup.4 is C.sub.1-7 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-2 alkyl, or a group (CH.sub.2).sub.t R.sup.5 where t is 1 or 2 and R.sup.5 is thienyl, pyrrolyl, or furyl, each optionally further substituted by one or two substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trifluoromethyl or halogen, or is phenyl optionally substituted by one or two substituents selected from C.sub.1-4 alkoxy, trifluoromethyl, halogen, nitro, carboxy, esterified carboxy, and C.sub.1-4 alkyl optionally substituted by hydroxy, C.sub.1-4 alkoxy, carboxy, esterified carboxy or in vivo hydrolyzable acyloxy; and the pharmaceutically acceptable salts, individual isomers, mixtures of isomers, processes for preparation, compositions, and methods of use thereof.
Inventor(s): Berger; Jacob (Los Altos Hills, CA), Clark; Robin D. (Palo Alto, CA), Eglen; Richard M. (Mountain View, CA), Smith; William L. (Sunnyvale, CA), Weinhardt; Klaus K. (San Francisco, CA)
Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA)
Application Number:07/704,565
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Drugs Protected by US Patent 5,202,333

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,202,333

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 124698 ➤ Subscribe
Australia 642178 ➤ Subscribe
Australia 6696390 ➤ Subscribe
Brazil 1100680 ➤ Subscribe
Canada 2030718 ➤ Subscribe
Germany 122005000027 ➤ Subscribe
Germany 69020694 ➤ Subscribe
Denmark 0430190 ➤ Subscribe
European Patent Office 0430190 ➤ Subscribe CA 2005 00023 Denmark ➤ Subscribe
European Patent Office 0430190 ➤ Subscribe 91162 Luxembourg ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Daiichi Sankyo
Covington
Express Scripts
Fuji
Medtronic
Harvard Business School
Federal Trade Commission
Deloitte

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