|Title:||Sustained and controlled release of water insoluble polypeptides|
|Abstract:||There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.|
|Inventor(s):||Orsolini; Piero (Martigny, CH), Mauvernay; Rolland-Yves (Lausanne, CH), Deghenghi; Romano (Lausanne, CH)|
|Assignee:||Debiopharm S.A. (Lausanne, CH)|
Patent Claim Types:|
see list of patent claims
|Composition; Process; Dosage form; Delivery; Formulation;|
|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||8722134||Sep 21, 1987|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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