Method of treating pulmonary hypertension with benzidine prostaglandins
The present invention is concerned with methods for the prophylaxis, treatment and diagnosis of pulmonary hypertension which comprise the administrative of an effective amount of a compound of formula (I) ##STR1## wherein a is an integer of from 1 to 3; X and Y, which may be the same or different, are selected from --O-- and --CH.sub.2 --; R is --(CH.sub.2).sub.5 R.sup.1 wherein R.sup.1 is hydrogen or methyl, or R is cyclohexyl, or R is --CH(CH.sub.3)CH.sub.2 C.tbd.CCH.sub.3 ; and the dotted line represents an optional double bond; or of a physiologically acceptable salt or acid derivative thereof. Medicaments and diagnostic aids for use in the methods of the invention are also within the scope of the invention.
Tadepalli; Anjaneyulu S. (Durham, NC), Long; Walker A. (Chapel Hill, NC), Crow; James W. (Raleigh, NC), Klein; Kenneth B. (Chapel Hill, NC)
Burroughs Wellcome Co. (Research Triangle Park, NC)
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