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Generated: November 24, 2017

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Details for Patent: 5,091,169

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Summary for Patent: 5,091,169

Title: Dipyridoxyl phosphate NMRI contrast agent compositions
Abstract:N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N'-bis-(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N'diaceti c acid, N,N'-bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N'-diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N'-bis(pyridoxal-5-phosphate)alkylenediimines, N,N'-bis(pyridoxal-5-phosphate)alkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N'-bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N'-bis(pyridoxal-5-phosphate)-1,2-arylenediamines, and the corresponding monophosphate compounds.
Inventor(s): Rocklage; Scott M. (Saratoga, CA), Quay; Steven C. (Los Altos Hills, CA)
Assignee: Salutar, Inc. (Sunnyvale, CA)
Application Number:07/370,429
Patent Claim Types:
see list of patent claims
Composition; Compound;

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International Patent Family for Patent: 5,091,169

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark251688► Subscribe
European Patent Office0290047► SubscribeC00290047/01Switzerland► Subscribe
European Patent Office0290047► SubscribeSPC/GB97/078United Kingdom► Subscribe
European Patent Office0290047► Subscribe97C0108Belgium► Subscribe
European Patent Office0290047► Subscribe67/1997Austria► Subscribe
Denmark173849► Subscribe
Germany19775088► Subscribe
Spain2066768► Subscribe
Finland882125► Subscribe
Germany3852906► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Novartis
Chinese Patent Office
UBS
Teva
Fish and Richardson
Moodys
Julphar
Accenture
Merck
Mallinckrodt

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