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Serving leading biopharmaceutical companies globally:

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Generated: January 16, 2018

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Details for Patent: 5,069,216

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Summary for Patent: 5,069,216
Title: Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract
Abstract:This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.
Inventor(s): Groman; Ernest V. (Brookline, MA), Josephson; Lee (Arlington, MA), Lewis; Jerome M. (Newton, MA)
Assignee: Advanced Magnetics Inc. (Cambridge, MA)
Application Number:07/409,384
Patent Claim Types:
see list of patent claims
Use; Composition;

Drugs Protected by US Patent 5,069,216

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,069,216

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 135920 ➤ Subscribe
Austria 139431 ➤ Subscribe
Austria 142891 ➤ Subscribe
Austria 143604 ➤ Subscribe
Austria 143814 ➤ Subscribe
Austria 151991 ➤ Subscribe
Australia 2545292 ➤ Subscribe
Australia 2700195 ➤ Subscribe
Canada 1301063 ➤ Subscribe
Canada 2075491 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Queensland Health
UBS
Daiichi Sankyo
Mallinckrodt
Fish and Richardson
Cerilliant
Chinese Patent Office
Deloitte
US Department of Justice

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