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Details for Patent: 5,019,583

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Summary for Patent: 5,019,583

Title: N-phenyl-N-(4-piperidinyl)amides useful as analgesics
Abstract:N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
Inventor(s): Feldman; Paul L. (Durham, NC), James; Michael K. (Raleigh, NC), Brackeen; Marcus F. (Durham, NC), Johnson; Michael R. (Chapel Hill, NC), Leighton; Harry J. (Chapel Hill, NC)
Assignee: Glaxo Inc. (Research Triangle Park, NC)
Application Number:07/448,497
Patent Claim Types:
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Compound; Composition; Dosage form; Use;

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