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Serving leading biopharmaceutical companies globally:

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Generated: November 20, 2017

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Details for Patent: 4,925,860

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Summary for Patent: 4,925,860

Title: Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
Abstract:Described is a stable pharmaceutical composition of 3-(hydroxymethyl-5,5-diphenylhydantoin disodium phosphate ester, the prodrug of 5,5-diphenylhydantoin (phenytoin) a commonly used drug for the treatment and management of epilepsy and other types of convulsive states. It has been found that degradation of the prodrug to phenytoin can be controlled by controlling the pH of the composition. Controlling the pH to between 8.3 to 9.4 results in the production of diphenylglycinamide as the primary degradant and minimization of degradation to phenytoin. If the pH is maintained at a lower or higher value, then the degradation pattern changes, with earlier than expected product failure.
Inventor(s): Herbranson; Dale E. (Lindenhurst, IL), Speicher; Earl R. (Buffalo Grove, IL), Rosenberg; Leonard S. (Flemington, NJ)
Assignee: E. I. Du Pont de Nemours and Company (Wilmington, DE)
Application Number:07/356,948
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Compound;

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International Patent Family for Patent: 4,925,860

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany69026253► Subscribe
Denmark0473687► Subscribe
European Patent Office0473687► SubscribeSPC/GB98/030United Kingdom► Subscribe
European Patent Office0473687► Subscribe99C0008Belgium► Subscribe
European Patent Office0473687► SubscribeC980045Netherlands► Subscribe
European Patent Office0473687► Subscribe3/1999Austria► Subscribe
Spain2086404► Subscribe
Finland101041► Subscribe
Hong Kong1006807► Subscribe
HungaryT61198► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Farmers Insurance
US Department of Justice
Argus Health

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