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Serving hundreds of leading biopharmaceutical companies globally:

Merck
Johnson and Johnson
Chubb
Fuji
McKinsey
Julphar
Harvard Business School
Dow
Teva

Generated: April 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,925,860

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Summary for Patent: 4,925,860
Title: Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
Abstract:Described is a stable pharmaceutical composition of 3-(hydroxymethyl-5,5-diphenylhydantoin disodium phosphate ester, the prodrug of 5,5-diphenylhydantoin (phenytoin) a commonly used drug for the treatment and management of epilepsy and other types of convulsive states. It has been found that degradation of the prodrug to phenytoin can be controlled by controlling the pH of the composition. Controlling the pH to between 8.3 to 9.4 results in the production of diphenylglycinamide as the primary degradant and minimization of degradation to phenytoin. If the pH is maintained at a lower or higher value, then the degradation pattern changes, with earlier than expected product failure.
Inventor(s): Herbranson; Dale E. (Lindenhurst, IL), Speicher; Earl R. (Buffalo Grove, IL), Rosenberg; Leonard S. (Flemington, NJ)
Assignee: E. I. Du Pont de Nemours and Company (Wilmington, DE)
Application Number:07/356,948
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Compound;

Drugs Protected by US Patent 4,925,860

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 4,925,860

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Germany 69026253 ➤ Sign Up
Denmark 0473687 ➤ Sign Up
European Patent Office 0473687 ➤ Sign Up SPC/GB98/030 United Kingdom ➤ Sign Up
European Patent Office 0473687 ➤ Sign Up 99C0008 Belgium ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

AstraZeneca
Colorcon
Farmers Insurance
Queensland Health
UBS
Healthtrust
Express Scripts
Dow
Federal Trade Commission

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