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Generated: November 19, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,916,246

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Summary for Patent: 4,916,246

Title: Paramagnetic chelates useful for NMR imaging
Abstract:Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3; b is an integer from 0 to 4; Me.sup.(a+) is Fe.sup.(2+), Fe.sup.(3+), Gd.sup.(3+), or Mn.sup.(2+) ; E.sup.(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b; m is an integer from 1 to 5; R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO.sub.3 H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH; R.sub.1 is the same as R.sub.2 or is --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ, CH.sub.2 CH.sub.2 --N(CH.sub.2 COOZ).sub.2, a hydroxy arylalkyl, hydroxy pyridylalkyl, hydroxy aryl(carboxy)alkyl or hydroxy pyridyl-(carboxy)alkyl radical, where the aryl or pyridyl radical may be substituted by hydroxyl, hydroxy alkyl, alkyl, halogen, carboxyl or SO.sub.3 H; R.sub.2 is --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ, ##STR2## wherein R.sub.3 is --CH.sub.2 COOZ, --CH(CH.sub.3)COOZ or a monovalent radical having the structure ##STR3## X is a direct chemical bond, --O--, --S--, --NH--, ##STR4## n is the integer 2 or 3, with the proviso that when X represents a direct bond, n is 1, 2 or 3; Z is hydrogen or a unit of negative charge, and --(CH.sub.2).sub.m -- may also be --CH.sub.2 --C(CH.sub.3).sub.2 --.
Inventor(s): Felder; Ernst (Riva S. Vitale, CH), Uggeri; Fulvio (Codogno, IT), Fumagalli; Luciano (Milan, IT), Vittadini; Giorgio (Milan, IT)
Assignee: Bracco Chimica S.p.A. (Milan, IT)
Application Number:07/002,115
Patent Claim Types:
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Foreign Priority and PCT Information for Patent: 4,916,246

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Italy19236 A/86Jan 30, 1986

International Patent Family for Patent: 4,916,246

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria120191► Subscribe
Austria53571► Subscribe
Australia2904789► Subscribe
Australia591225► Subscribe
Australia620841► Subscribe
Australia6753987► Subscribe
Canada1324150► Subscribe
Germany19875036► Subscribe
Germany3763189► Subscribe
Germany3853415► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Serving leading biopharmaceutical companies globally:

US Department of Justice
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