Details for Patent: 4,837,223
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Summary for Patent: 4,837,223
| Title: | (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide compositions |
| Abstract: | (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X--CH.sub.2 CH.sub.2 -NHCH (C.sub.2 H.sub.5)CONH.sub.2 wherein Y is a --CH.sub.2 --radical when X represents a ZOOC--radical and Y is a --CO-- radical when X represents a HalCH.sub.2 --radical, Z being a C.sub.1 -C.sub.4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate. |
| Inventor(s): | Gobert; Jean (Brussels, BE), Geerts; Jean-Pierre (Leglise, BE), Dodson; Guy (Bellefontaine, BE) |
| Assignee: | UCB Societe Anonyme (Brussels, BE) |
| Application Number: | 07/025,277 |
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Patent Claim Types: see list of patent claims | Composition; Compound; Process; |
Drugs Protected by US Patent 4,837,223
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 4,837,223
| Foriegn Application Priority Data | ||
| Foreign Country | Foreign Patent Number | Foreign Patent Date |
| United Kingdom | 84/12357 | May 15, 1984 |
International Family Members for US Patent 4,837,223
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Austria | 45348 | ⤷ Try a Trial | |||
| Austria | 45567 | ⤷ Try a Trial | |||
| Australia | 4252985 | ⤷ Try a Trial | |||
| Australia | 4253085 | ⤷ Try a Trial | |||
| Australia | 574175 | ⤷ Try a Trial | |||
| Australia | 574465 | ⤷ Try a Trial | |||
| Bulgaria | 47497 | ⤷ Try a Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
