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Serving leading biopharmaceutical companies globally:

Harvard Business School
US Army
Cipla
McKesson
Accenture
Colorcon
Fish and Richardson
McKinsey
Novartis
Queensland Health

Generated: February 21, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,800,191

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Summary for Patent: 4,800,191
Title: LHRH antagonists
Abstract:The present invention deals with LHRH antagonists which possess improved water solubility and while having the high antagonist potency of the basic peptides, are free of the edematogenic effects. These compounds are highly potent in inhibiting the release of gonadotropins from the pituitary gland in mammals, including humans. The compounds of this invention are represented by the formula wherein X is an acyl group derived from straight or branched chain aliphatic or alicyclic carboxylic acids having from 1 to 7 carbon atoms, R.sup.1 is D- or L-Pro, D- or L- .DELTA. .sup.3 -Pro, D-Phe, D-Phe(4-H1), D-Ser, D-Thr, D-Ala, D-Nal (1) or D-Nal (2), R.sup.2 is D-Phe or D-Phe(4-H1) R.sup.3 is D-Trp, D-Phe, D-Pal, D-Nal(1) or D-Nal (2), R.sup.6 is D-Cit, D-Hci, D-Cit(Q) or D-Hci(Q) and R.sup.10 is Gly or D-Ala where Q is lower alkyl of 1-3 carbon atoms and H1 is fluoro, chloro or bromo, and the pharmaceutically acceptable acid addition salts thereof and methods of use pertaining to these compounds.
Inventor(s): Schally; Andrew V. (Metarie, LA), Bajusz; Sandor (New Orleans, LA)
Assignee:
Application Number:07/074,126
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Drugs Protected by US Patent 4,800,191

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 4,800,191

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Brazil 1100478 ➤ Sign Up
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Germany 19975052 ➤ Sign Up
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European Patent Office 0299402 ➤ Sign Up C990029 Netherlands ➤ Sign Up
European Patent Office 0299402 ➤ Sign Up 099C0031 Belgium ➤ Sign Up
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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
US Department of Justice
Teva
Citi
Boehringer Ingelheim
Covington
Baxter
UBS
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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