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Johnson and Johnson
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Fish and Richardson

Generated: October 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,695,578

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Summary for Patent: 4,695,578

Title: 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
Abstract:The invention relates to compounds of formula (I). ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group, and one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-(C.sub.1-3) alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; and physiologically acceptable salts and solvates, e.g. hydrates thereof. The compounds are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.
Inventor(s): Coates; Ian H. (Hertfordshire, GB2), Bell; James A. (Royston, GB2), Humber; David C. (Ealing, GB2), Ewan; George B. (Gerrard's Cross, GB2)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:06/931,032
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

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Foreign Priority and PCT Information for Patent: 4,695,578

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8401888Jan 25, 1984
United Kingdom8425959Oct 15, 1984
United Kingdom8501727Jan 23, 1985
United Kingdom8501728Jan 23, 1985

International Patent Family for Patent: 4,695,578

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain556101► Subscribe
Germany3502508► Subscribe
Germany3680123► Subscribe
Germany19375046► Subscribe
Denmark35785► Subscribe
Denmark169521► Subscribe
European Patent Office0191562► Subscribe
Spain539852► Subscribe
Spain8609309► Subscribe
Spain548430► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Farmers Insurance
Daiichi Sankyo
Express Scripts
Boehringer Ingelheim

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