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Generated: May 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,695,578

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Summary for Patent: 4,695,578
Title: 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
Abstract:The invention relates to compounds of formula (I). ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group, and one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-(C.sub.1-3) alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; and physiologically acceptable salts and solvates, e.g. hydrates thereof. The compounds are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.
Inventor(s): Coates; Ian H. (Hertfordshire, GB2), Bell; James A. (Royston, GB2), Humber; David C. (Ealing, GB2), Ewan; George B. (Gerrard's Cross, GB2)
Assignee: Glaxo Group Limited (London, GB2)
Application Number:06/931,032
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 4,695,578
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Drugs Protected by US Patent 4,695,578

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 4,695,578

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8401888Jan 25, 1984
United Kingdom8425959Oct 15, 1984
United Kingdom8501727Jan 23, 1985
United Kingdom8501728Jan 23, 1985

International Family Members for US Patent 4,695,578

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 392276 ➤ Try a Free Trial
Austria A20485 ➤ Try a Free Trial
Australia 3809785 ➤ Try a Free Trial
Australia 5261486 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Citi
Daiichi Sankyo
Chinese Patent Office
Medtronic
Merck
Cantor Fitzgerald
Cerilliant
Boehringer Ingelheim

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