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Details for Patent: 4,631,286

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Summary for Patent: 4,631,286

Title: 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
Abstract:There are disclosed compounds having the formula ##STR1## wherein X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, NHCOR.sub.2 wherein R.sub.2 is loweralkyl, or a group of the formula NR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R and R.sub.1 are independently hydrogen, loweralkyl, phenylloweralkyl, phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl, diphenylloweralkyl or diphenylloweralkyl in which one or both phenyl groups are substituted by one or more loweralkyl, loweralkoxy, halogen, hydroxy or trifluoromethyl; Y is C.dbd.O or CR.sub.5 OH wherein R.sub.5 is hydrogen or loweralkyl; Z is CH.sub.2 or C.dbd.CR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR.sub.5 .dbd.CH wherein CR.sub.5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
Inventor(s): Shutske; Gregory M. (Somerset, NJ), Pierrat; Frank A. (Somerset, NJ)
Assignee: Hoechst-Roussel Pharmaceuticals Inc. (Somerville, NJ)
Application Number:06/664,731
Patent Claim Types:
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Compound; Composition; Use;

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International Patent Family for Patent: 4,631,286

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark141992► subscribe
Australia3823489► subscribe
Australia615768► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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