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Details for Patent: 4,619,939

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Summary for Patent: 4,619,939

Title: Process for reducing intraocular pressure
Abstract:Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar; e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.
Inventor(s): Maren; Thomas H. (Gainesville, FL)
Assignee: University of Florida (Gainesville, FL)
Application Number:06/729,907
Patent Claim Types:
see list of patent claims
Use; Formulation; Process; Composition; Dosage form;

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International Patent Family for Patent: 4,619,939

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Denmark376281► subscribe
Germany3411104► subscribe
European Patent Office0044134► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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