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|Title:||Process for reducing intraocular pressure|
|Abstract:||Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar; e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.|
|Inventor(s):||Maren; Thomas H. (Gainesville, FL)|
|Assignee:||University of Florida (Gainesville, FL)|
Patent Claim Types:|
see list of patent claims
|Use; Formulation; Process; Composition; Dosage form;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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