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Last Updated: April 24, 2024

Details for Patent: 4,619,939

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Summary for Patent: 4,619,939

Title:	Process for reducing intraocular pressure
Abstract:	Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3; b. ether partition coefficient of at least 1.0; c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar; e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ; f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.
Inventor(s):	Maren; Thomas H. (Gainesville, FL)
Assignee:	University of Florida (Gainesville, FL)
Application Number:	06/729,907
Patent Claim Types: see list of patent claims	Use; Formulation; Process; Composition; Dosage form;

Drugs Protected by US Patent 4,619,939

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

International Family Members for US Patent 4,619,939

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	13632	⤷ Try a Trial
Belgium	899314	⤷ Try a Trial
Canada	1192560	⤷ Try a Trial
Canada	1193546	⤷ Try a Trial
Switzerland	659585	⤷ Try a Trial
Germany	3170818	⤷ Try a Trial
Germany	3411104	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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