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Details for Patent: 4,517,181

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Summary for Patent: 4,517,181

Title: Mammalian PGRF
Abstract:PGRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: ##STR1## wherein R is OH or NH.sub.2, R.sub.34 is Ser or Ala, R.sub.38 is Arg or Ser, R.sub.40 is Ala or Arg and R.sub.41 is Arg, Arg-Ala, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R.sub.41. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically.
Inventor(s): Ling; Nicholas C. (San Diego, CA), Esch; Frederick S. (Oceanside, CA), Bohlen; Peter (Encinitas, CA), Brazeau, Jr.; Paul E. (San Diego, CA), Guillemin; Roger C. L. (La Jolla, CA)
Assignee: The Salk Institute for Biological Studies (San Diego, CA)
Application Number:06/418,248
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

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International Patent Family for Patent: 4,517,181

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Finland79716► subscribe
Finland832176► subscribe
Spain523277► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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